Journal of Clinical Developmental Biology

The underdiagnosis of cryoglobulinemias, a potentially big problem at the long term

Purpose: To evaluate the prevalence of cryoglobulinemias, as well as it,s commorbidities and ethiology Autoimmune diseases could very well be referred to as a spectrum too, being that in most cases you find some form of other autoinmune disease overlapped. But what about cryoglobulinemia? Could this disease go very much undiagnosed, despite suspecting an autoinmune disorder?Cryoglobulins are immunoglobulins that precipitate at temperaturas below 37ºC. They Usually redissolveUpon rewarming.Clinically, it usually presents with púrpura (a purplish discoloration from bleeding under the skin.) It also usually presents with severe joint pain and muscle pain (something known as Metzler´s Triad).The problem is that sometimes these immuneglobulins attach together and form immunecomplexes, which compromise blod flow and can hurt certain organs such as the kidneys and the liver. But are we including the look for cryoglobulins when we think about an autoinmune disorder?

It has always been known to be connected to either the hepatitis C virus or to Waldestroms Macroglobulinemia.

Author(s):

Dr.Melchor Rodrigo

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